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. 2017 May 7;8(29):47425–47439. doi: 10.18632/oncotarget.17659

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Copyright: © 2017 Lee et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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The scheme illustrates the proposed mechanism of α-mangostin-induced apoptosis in cervical cancer. Alpha-mangostin enhances ROS content to activate ASK/p38 signaling pathway and damage the integrity of mitochondria, including loss of MMP, increase of Bax and cytochrome C release, and decrease of Bcl-2, leading to activation of caspase-9/caspase-3 cascade and induction of apoptosis in cervical cancer cells.