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. 2017 Apr 27;8(29):47642–47654. doi: 10.18632/oncotarget.17465

Figure 1. αMSH weakens LPS-induced adipose inflammation by inhibiting FoxOs expressions in mice.

Figure 1

(A) Serum protein levels of IL-1β, IL-6, IL-4 and IL-10 after mice with LPS or saline intraperitoneal injection (n=6). (B) Measurement of serum αMSH level before and after LPS or saline intraperitoneal injection (n=6). Epididymis white adipose tissue was isolated after intraperitoneal injection with LPS or saline, then mRNA levels of MC5R (C), Foxo1, Foxo3a, Foxo4 and Foxo6 (D) were detected (n=6). Base on the LPS/saline injection, mice were injected with another 500 nM αMSH, then further detected for relative serum protein levels of IL-1β, IL-6, IL-4 (E) and mRNA levels of M1, M2 markers (F), MC5R (G), IL-6, MCP-1, Leptin (H), Foxo1, Foxo3a, Foxo4 and Foxo6 (I) in white adipose tissue (n=6). Values are means ± SD. vs. control group, * P < 0.05.