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. 2017 Apr 27;8(29):47642–47654. doi: 10.18632/oncotarget.17465

Figure 2. FoxOs reverse the inhibition of αMSH on adipose inflammation in mice.

Figure 2

Mice white adipose tissue was isolated after intraperitoneal injection with pAd-Foxo1 and with another 500 nM αMSH, then mRNA levels of Foxo1, MC5R (A), M1, M2 markers (C), IL-6, MCP-1, Leptin (D) were measured (n=6). After intraperitoneal injection with pAd-Foxo1 and with another 500 nM αMSH, serum protein levels of IL-1β, IL-6, IL-4 and IL-10 (B) were detected (n=6). After intraperitoneal injection with pAd-Foxo3a and with another 500 nM αMSH to mice, mRNA levels of Foxo3a, MC5R (E), M1, M2 markers (G), IL-6, MCP-1, Leptin (H) were measured in white adipose tissue (n=6). Serum protein levels of IL-1β, IL-6, IL-4 and IL-10 (F) were also detected (n=6). Mice were intraperitoneal injected with pAd-Foxo4 and another 500 nM αMSH, serum protein levels of IL-1β, IL-6, IL-4 and IL-10 (J) and mRNA levels of Foxo4, MC5R (I), M1, M2 markers (K), IL-6, MCP-1, Leptin (L) were measured (n=6). Values are means ± SD. vs. control group, * P < 0.05.