Table 2. Relationship between NDRG1 and clinicopathologic variables.

Variable	Case	NDRG1 expression		P value
		Positive	Negative
	n=97	n=57	n=40
Age (years)				0.520
≤65	52	29	23
>65	45	28	17
Gender				0.119
Male	72	39	33
Female	25	18	7
ECOG performance				0.183
0	68	37	31
1	29	20	9
Tumor size (cm)				0.001
≤4 ×3	52	39	13
>4 ×3	45	18	27
Location from anal verge				0.290
0-5cm	52	28	24
5-10cm	45	29	16
Local invasion				0.002
T2	26	22	4
T3+T4	71	35	36
Lymphatic invasion				0.005
N0	27	22	5
N1+N2	70	35	35
TNM stage				0.005
II	27	22	5
III	70	35	35

The staging results were determined by two independent pathologists according to the 7th edition of the AJCC Cancer Staging system.