. 2017 May 9;8(29):47725–47740. doi: 10.18632/oncotarget.17730

Table 3. Class I PI3K and mTOR IC₅₀ values for SN32976 and its major metabolites.

IC₅₀ (nM)	PI3Kα^a	PI3Kβ^a	PI3Kγ^a	PI3Kδ^a	mTOR^b
SN32976	15.1 ± 4.3	461 ± 195	110 ± 41	134 ± 20	194 ± 55
M8	5.8 ± 0.4	108 ± 27	68.0 ± 18.6	37.6 ± 13.5	156 ± 44
M9	8.2 ± 1.8	61.5 ± 21.2	90.3 ± 17.1	45.8 ± 17.7	244 ± 56
M17	6.2 ± 0.5	>1000	26.3 ± 2.6	55.0 ± 24.1	74.9 ± 25.1

^a IC₅₀ values (mean ± SEM, n≥3) determined by HTRF assay.

^b IC₅₀ values (mean ± SEM, n=2) determined by Invitrogen.

Table 3. Class I PI3K and mTOR IC50 values for SN32976 and its major metabolites.