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(A) Putative binding sequences of IGF1R and mTOR with complementary sites for the seed regions of miR-99a and miR-497, as shown. (B) The analysis of the relative luciferase activities of IGF1R-WT and IGF1R-Mut in the Hep3B cells. (C) The analysis of the relative luciferase activities of mTOR-WT and mTOR-Mut in the Hep3B cells. NC: negative control microRNA. *P<0.05, **P<0.005, ***P<0.001, compared to NC.
