Table 4. Best gene–gene interaction models, as identified by GMDR.
| Locus no. | Best combination | Cross-validation consistency | Testing accuracy | p-values* |
|---|---|---|---|---|
| Gene- gene interaction | ||||
| 2 | rs1784933 rs1805192 | 9/10 | 0.6270 | 0.0010 |
| 3 | rs1784933 rs1805192 rs10865710 | 8/10 | 0.5399 | 0.0547 |
| 4 | rs1784933 rs1805192 rs10865710 rs3824966 | 7/10 | 0.5399 | 0.1719 |
| 5 | rs1784933 rs1805192 rs10865710 rs3824966 rs689021 | 7/10 | 0.4958 | 0.3770 |
| 6 | rs1784933 rs1805192 rs10865710 rs3824966 rs689021 rs709158 | 6/10 | 0.4958 | 0.4258 |
| Gene- environment interaction | ||||
| 2 | rs1784933 alcohol drinking | 10/10 | 0.6072 | 0.0100 |
| 3 | rs1784933 rs1805192 alcohol drinking | 8/10 | 0.5399 | 0.1719 |
| 4 | rs1784933 rs1805192 rs10865710 alcohol drinking | 7/10 | 0.5399 | 0.1719 |
| 5 | rs1784933 rs1805192 rs10865710 rs3824966 alcohol drinking | 6/10 | 0.4958 | 0.4258 |
| 6 | rs1784933 rs1805192 rs10865710 rs3824966 rs689021 alcohol drinking | 5/10 | 0.4958 | 0.3770 |
| 7 | rs1784933 rs1805192 rs10865710 rs3824966 rs689021 rs709158 alcohol drinking | 6/10 | 0.4958 | 0.9893 |
*Adjusted for gender, age, smoking and alcohol status, BMI, WC, FPG, TC, TG, HDL, educational year, prevalence of stroke, prevalence of diabetes.