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TAMs interact with tumor cells and other tumor-infiltrating immune cells to influence tumor angiogenesis, invasion as well as metastasis. Some of the interactions mentioned in this review are depicted in the figure. TAM, tumor-associated macrophage; CAF, cancer-associated fibroblast; MDSC, myeloid-derived suppressor cell; NK, natural killer cell; DC, dendritic cell; Treg, regulatory T cell; EC, endothelial cell.
