| Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells |
Valadi, Hadi |
NATURE CELL BIOLOGY |
2007 |
255.73 |
Exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location. |
| Extracellular vesicles: Exosomes, microvesicles, and friends |
Raposo, Graca |
JOURNAL OF CELL BIOLOGY |
2013 |
147.8 |
In this review, they focus on the characterization of EVs and on currently proposed mechanisms for their formation, targeting, and function. |
| Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET |
Peinado, Hector |
NATURE MEDICINE |
2012 |
119.67 |
Exosome production, transfer and education of bone marrow cells supports tumor growth and metastasis |
| Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes |
Alvarez-Erviti, Lydia |
NATURE BIOTECHNOLOGY |
2011 |
98.43 |
The therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA (60%) and protein (62%) knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice. |
| MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer |
Taylor, Douglas D. |
GYNECOLOGIC ONCOLOGY |
2008 |
82 |
icroRNA profiling of circulating tumor exosomes could potentially be used as surrogate diagnostic markers |
| Ceramide triggers budding of exosome vesicles into multivesicular Endosomes |
Trajkovic, Katarina |
SCIENCE |
2008 |
70.4 |
Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. |
| Exosomes: Extracellular organelles important in intercellular communication |
Mathivanan, Suresh |
JOURNAL OF PROTEOMICS |
2010 |
65.12 |
In this review they focus on various strategies for purifying exosomes and discuss their biophysical and biochemical properties. |
| Functional delivery of viral miRNAs via exosomes |
Pegtel, D. Michiel |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
2010 |
65 |
miRNA-mediated gene silencing as a potential mechanism of intercellular communication between cells of the immune system may be exploited by the persistent human gamma-herpesvirus EBV |
| Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells |
Mittelbrunn, Maria; |
NATURE COMMUNICATIONS |
2011 |
64.29 |
Cellular communication involving antigen-dependent, unidirectional intercellular transfer of miRNAs may be related to exosomes during immune synapsis |
| Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles |
Colombo, Marina; |
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 |
2014 |
63.75 |
This review focuses on the definition of exosomes and other secreted extracellular vesicles. |
