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. 2017 Jun 1;8(30):48563–48574. doi: 10.18632/oncotarget.18335

Figure 1. High-fat diet induces hepatic IL-33 expression.

Figure 1

Wild type mice received a HFD or a standard diet SD for 12 weeks. A. Relative mRNA expression of IL-33, and its membrane and soluble receptors ST2-L and ST2-s in livers from SD- and HFD-fed mice. The y-axis values represent the induction of each gene relative to control (SD-fed mice) after normalization using 18S. B. Immunolocalization of IL-33 in the livers of SD- and HFD-fed mice. Cellular staining is shown in the insets. Scale bars = 250 μm. Statistical analysis of the data was performed using the non-parametric Mann-Whitney U-test. Differences were considered to be significant for p < 0.05 and are indicated as follows: ***p < 0.001.