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. 2017 Jun 1;8(30):48563–48574. doi: 10.18632/oncotarget.18335

Figure 3. IL-33 deficiency does not alter the inflammatory features of steatohepatitis in mice fed the high-fat diet.

Figure 3

A. Representative liver histology (HE coloration) for IL-33 KO mice and WT littermates fed HFD or SD. Ballooning hepatocytes are shown in the insets. Scale bar = 250 μm. B. Levels of serum ALT and AST (UI/L) at weeks 6, 10 and 12 in WT and IL-33 KO mice fed a HFD. C. Relative mRNA transcript levels of IL-6, IL-1β, TNF-α, IL-23, CCL20 and SAA in livers. The y-axis values represent the induction of each gene relative to control (SD-fed WT mice) after normalization using 18S. Statistical analysis of the data was performed using the non-parametric Mann-Whitney U-test. Differences were considered to be significant for p < 0.05 and are indicated as follows: *p < 0.05, ***p < 0.001, ns: non-significant.