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. 2017 Jun 1;8(30):48563–48574. doi: 10.18632/oncotarget.18335

Figure 4. Evolution of diet-induced steatohepatitis towards fibrosis is not affected by IL-33 deficiency.

Figure 4

A. Representative liver sections stained with Sirius red from WT and IL-33 KO mice fed either SD or HFD. Scale bar = 250μm. B. Area of fibrosis according to the percentage of total liver sections stained with Sirius red in WT and IL-33 KO mice fed the HFD. C. Relative mRNA transcript levels of the fibrosis markers TIMP-2, Col 1α, α-SMA, and TGF-β in liver. The y-axis values represent the induction of each gene relative to control (SD-fed WT mice) after normalization using 18S. Statistical analysis of the data was performed using the non-parametric Mann-Whitney U-test. Differences were considered to be significant for p < 0.05 and are indicated as follows: *p < 0.05, **p < 0.01, ***p < 0.001, ns: non-significant.