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. 2017 Mar 23;8(30):48889–48904. doi: 10.18632/oncotarget.16522

Figure 6. TIPE3 promotes tumorigenesis and metastasis of human breast cancer in vivo.

Figure 6

Compared with the group injected with pRK5-Ctrl, the numbers of nude mice appearing tumors are more in the group injected with pRK5-TIPE3. The growth curves of tumors in nude mice injected with pRK5-Ctrl and pRK5-TIPE3 plasmid (A). (B) showed the representative image of isolated tumors. The mean tumor volume and weight in TIPE3 group (n =7) was higher than that of pRK5-Ctrl group (n =7) (C and D). The expression of TIPE3 in tumor tissues was detected by WB and immunohistochemistry (E). The numbers of metastatic foci per section in lung of individual nude mice with injection of MDA-MB-231-shTIPE3 or its shCtrl cells (F). All of the experiments were repeated at least three times with similar results and representative data are shown. (*P < 0.05, **P < 0.01 and ***P < 0.001).