Figure 8. Inhibiting the NF-κB and AKT signaling blocks the TIPE3 effects on proliferation and migration of breast cancer cells.

CAPE or LY294002 could block the enhanced proliferation (A), colony formation (C), and migration (E) abilities induced by overexpressed TIPE3 in MCF-7 cells or MDA-MB-231 cells (B, D and F, respectively). All of the experiments were repeated at least three times with similar results and representative data are shown. (*P < 0.05, **P < 0.01 and ***P < 0.001).