Table 1. Relationship between TIPE3 expression in breast cancer and clinical pathological features of patients.
| Clinicalpathologicalfeatures | Number ofcases | Expression of TIPE3 | P -value | r | |||
|---|---|---|---|---|---|---|---|
| − | + | ++ | +++ | ||||
| Pathology diagnosis | |||||||
| Adjacent tissues | 25 | 15 | 9 | 1 | 0 | < 0.001 | |
| Cancer tissues | 96 | 6 | 27 | 31 | 32 | ||
| DCIS* | 10 | 1 | 5 | 3 | 1 | 0.007 | |
| Invasive cancer with DCIS* | 24 | ||||||
| DCIS tissues | 24 | 2 | 11 | 7 | 4 | ||
| Invasive cancer tissues | 24 | 1 | 5 | 8 | 10 | ||
| Invasive cancer* | 62 | 4 | 17 | 20 | 21 | ||
| Her2 status | |||||||
| Low | 29 | 2 | 11 | 9 | 7 | 0.024 | 0.325 |
| High | 19 | 1 | 2 | 6 | 10 | ||
| Age at diagnosis | |||||||
| < 50 | 49 | 4 | 14 | 16 | 15 | 0.851 | |
| ≥ 50 | 47 | 2 | 13 | 15 | 13 | ||
| Tumor size | |||||||
| ≤ 2.0cm | 24 | 2 | 7 | 6 | 9 | 0.831 | |
| > 2.0cm | 24 | 1 | 6 | 9 | 8 | ||
| ER status | |||||||
| Low | 20 | 1 | 4 | 10 | 5 | 0.863 | |
| High | 28 | 2 | 9 | 5 | 12 | ||
| PR status | |||||||
| Low | 23 | 1 | 5 | 8 | 9 | 0.385 | |
| High | 25 | 2 | 8 | 7 | 8 | ||
Note: P < 0.001, TIPE3 protein in Adjacent tissues vs TIPE3 in Cancer tissues.
P* = 0.007, TIPE3 protein in DCIS tissues vs TIPE3 in invasive tissues.
P = 0.024, TIPE3 protein in low HER2 status tissues vs in high HER2 status tissues.
DCIS: ductal carcinoma in situ.
Her2: human epidermal growth factor receptor 2.
ER: estrogen receptor.
PR: progesterone receptor.