The clustering was based on the expression data of differentially expressed genes between tumor samples and non-tumor samples in hepatocellular carcinoma. PRMS: predicted risk metastasis signature. ALT: alanine aminotransferase. TNM: Tumor Node Metastasis. BCLC: Barcelona Clinic Liver Cancer. CLIP: Cancer of the Liver Italian Program. AFP: alpha-fetoprotein. The red color represented high metastasis risk, female, high ALT levels (> 50 U/L), large tumor size (> 5 cm), multinodular, cirrhosis and high AFP levels (> 300 ng/ml). The color intensity was proportional to older age and higher stage of TNM, BCLC and CLIP.