Table 1. Hub genes in the module related with metastasis risk.

Gene	Probe	Co-expression analysis			Hub gene inPPI network	DEG analysis
		p.Weighted	q.Weighted	cor.Weighted		logFC	FDR
ABAT	209459_s_at	0	0	−0.85	YES	−1.80	8.77E-54
AGXT	210326_at	0	0	−0.80	YES	−1.88	5E-38
ALDH6A1	221590_s_at	0	0	−0.83	YES	−2.26	1.98E-63
CYP4A11	211231_x_at	0	0	−0.81	YES	−2.53	3.28E-86
DAO	206878_at	0	0	−0.83	YES	−1.38	2.75E-33
EHHADH	205222_at	0	0	−0.81	YES	−1.55	7.15E-45
ABCA6	217504_at	0	0	−0.80	NO	−1.55	6.37E-42
AGXT2L1	221008_s_at	0	0	−0.82	NO	−2.53	5.85E-44
ALDH2	201425_at	0	0	−0.85	NO	−1.50	4.39E-68
ALDH5A1	203608_at	0	0	−0.81	NO	−1.03	9.4E-29
ALDOB	204704_s_at	0	0	−0.83	NO	−2.90	4.04E-57
APOC4	206738_at	0	0	−0.85	NO	−2.07	2.73E-40
CAT	201432_at	0	0	−0.84	NO	−1.18	2.23E-49
CES2	213509_x_at	0	0	−0.83	NO	−1.41	9.92E-31
CYB5A	207843_x_at	0	0	−0.80	NO	−0.72	1.26E-21
DCXR	217973_at	0	0	−0.88	NO	−1.87	4.93E-53
DHRS1	213279_at	0	0	−0.83	NO	−1.73	6.04E-59
EPHX2	209368_at	0	0	−0.82	NO	−1.95	1.06E-59
F13B	207810_at	0	0	−0.81	NO	−0.85	2.7E-11
FMO4	206263_at	0	0	−0.83	NO	−1.26	8.51E-32
GLYAT	222083_at	0	0	−0.82	NO	−3.57	1.87E-90
GYS2	214621_at	0	0	−0.81	NO	−3.42	1.93E-81
HAGH	205012_s_at	0	0	−0.88	NO	−1.29	2.92E-43
HGD	205221_at	0	0	−0.80	NO	−1.59	4.94E-40
HRSP12	203790_s_at	0	0	−0.81	NO	−1.48	1.18E-43
HSD17B6	37512_at	0	0	−0.81	NO	−1.87	7.7E-30
PCK2	202847_at	0	0	−0.87	NO	−1.53	3.88E-49
PXMP2	219076_s_at	0	0	−0.82	NO	−1.08	1.48E-32
RGN	210751_s_at	0	0	−0.81	NO	−1.47	3.99E-51
SEC14L2	204541_at	0	0	−0.87	NO	−1.78	2.27E-53
SERPINC1	210049_at	0	0	−0.82	NO	−1.09	1.34E-16
SLC10A1	207185_at	0	0	−0.85	NO	−3.04	2.13E-50
SLC27A5	219733_s_at	0	0	−0.90	NO	−2.62	3.86E-66
SULT2A1	206292_s_at	0	0	−0.85	NO	−1.77	1.62E-28

Abbreviations: PPI: protein-protein interaction. FC: fold change. DEG: differentially expressed genes. FDR: false discovery rate.