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. 2017 Mar 17;8(30):49110–49122. doi: 10.18632/oncotarget.16308

Figure 6. miR-196a-3p inhibits the proliferation and metastasis of MDA-MB-231 cells in vivo.

Figure 6

(A) Nude mice were challenged in the mammary fat with MDA-MB-231 cells to form xenograft tumors, and miR-196a-3p or control agomir was injected into the tumors. Tumor volumes and weights were monitored. ns:nonsignificance, p=0.1662. (B) MDA-MB-231 cells were randomly injected into nude mice via tail vein, followed by administration of miR-196a-3p or control agomir. Metastatic nodules in the lung were observed. Representative lungs were photographed and HE staining of lungs was performed. The results are means of three independent experiments ± S.D. (**p< 0.01). (C) Immunohistochemical staining of Ki67 and NRP2 in xenograft tumor tissues. **p<0.01 (×200). (miR-196a-3p-A: miR-196a-3p-agomir; Con-A:Control agomir)