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. 2017 Apr 13;8(30):49133–49143. doi: 10.18632/oncotarget.17099

Figure 2. The TMEM219-TAOK2 fusion transcript.

Figure 2

(A) The fusion transcript was detected from the VCaP, DU145, PC3, 22Rv1, NCI-H660 and LNCaP cell lines (see Supplementary Table 2), and the specific breakpoint was verified by Sanger sequencing. (B) Example data from the TCGA prostate tumor “TCGA-HC-7211-01A-11R-2118-07” shows seven split reads spanning the chimeric transcript breakpoint, from exon 5 of TMEM219 (ENST00000414689) to exon 2 of TAOK2 (ENST00000279394). The fusion transcript is predicted to include an in-frame open reading frame encoding a chimeric protein with the combination of transmembrane and serine/threonine kinase domains. The genomic view of the fusion event is from the top showing annotated exons of the fusion partner genes and the number of split reads supporting breakpoint (curved line), the RNA expression levels (read counts), and genomic coordinates for the fusion transcript in mega base pairs from the p-telomere of chromosome 16.