Figure 1. mRNA expression levels of enzymes involved in glucose metabolism in IDH1^WT versus IDH1^MUT glioma.

IDH1^WT glioma show higher expression levels of genes that are typically upregulated in glycolytic cancer cells. (A) Analysis of gene expression levels of metabolic enzymes involved in transport and metabolism of glucose in IDH1^WT (n = 399) and IDH1^MUT (n = 112) LGG and IDH1^WT (n = 157) and IDH1^MUT (n = 9) glioblastoma samples obtained from the TCGA database. Relative mRNA expression levels are shown for IDH1^WT (blue) and IDH1^MUT (red). (B) LDHA and (C) LDHB expression and methylation according to IDH1^MUT status (blue: IDH1^WT, red: IDH1^MUT). Abbreviations: GLUT, glucose transporter; HK, hexokinase; G6PD, glucose-6-phosphate dehydrogenase; PK, pyruvate kinase; LDH, lactate dehydrogenase.