Figure 2. Expression levels of genes of enzymes involved in the TCA cycle in IDH1^WT versus IDH1^MUT glioma.

Increased TCA upstream of isocitrate, but decreased metabolism downstream of isocitrate in IDH1^MUT glioma as indicated by gene expression levels of enzymes involved in the TCA cycle in IDH1^WT (n = 399) and IDH1^MUT (n = 112) LGG and IDH^1WT (n = 157) and IDH1^MUT (n = 9) glioblastoma. Relative mRNA expression levels are shown for IDH1^WT (blue) and IDH1^MUT (red). Abbreviations: PDH, pyruvate dehydrogenase; PDK, pyruvate dehydrogenase kinase; CS, citrate synthase; ACO, aconitase; IDH, isocitrate dehydrogenase; a-KGDH, α-ketoglutarate dehydrogenase; SDH, succinate dehydrogenase; FH, fumarate hydratase; MDH, malate dehydrogenase.