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. 2017 May 3;8(30):49318–49328. doi: 10.18632/oncotarget.17595

Figure 2. Effects of sestrin 2 overexpression on cell proliferation and apoptosis in CRC cells.

Figure 2

(A) Cell growth curves indicate significantly reduced growth in LV-sestrin 2 cells compared with cells in the BC and LV-NC control groups. (B) Plate clone formation assay. Colony numbers were significantly decreased in SW620 and LoVo cells in the LV- sestrin 2 group, compared with the BC and LV-NC groups. (C) Apoptosis assay. The percentage of apoptotic cells was significantly increased in the LV-sestrin 2 group compared with the BC and LV-NC groups. “BC”, blank control group; “LV-NC”, negative control group; “LV- sestrin 2”, sestrin 2 overexpression group. *p < 0.05 indicates statistically significant differences between LV-sestrin 2 group and BC or LV-NC control groups.