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. 2017 May 4;8(30):49329–49337. doi: 10.18632/oncotarget.17632

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Copyright: © 2017 Satelli et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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CSV CTC counts and PSA levels independently associate with castration resistance: Both CSV CTC counts (A) and PSA levels (C) but not CellSearch (B) are independent, and unrelated biomarkers of castration resistance in peripheral blood samples. Generalized poisson mixed regression was applied for CTC counts resulting in a P < 0.001 for (A) and P = 0.852 for (B). For PSA score, generalized log-normal mixed regression was applied which showed a similar P < 0.001 (C). CSV CTC count was significantly correlated to CellSearch CTC count (P = 0.003) using Spearman's rank correlation due to the non-normality of the data (D). Patient numbers for hormone sensitive and castration resistant groups are n = 10 and 38, respectively. PSA change (E) from time of liquid biopsy acquisition and 6 months afterwards did not show a significant difference between the two groups. Calculation of a CTC index as determined by the division of a patients CSV CTC count by the combined count of CSV and CellSearch did not yield a statistically significant difference (F).