Table 2. Mixed evidence of 1-year overall survival and recurrence-free survival for different treatments.
| 1-year RFS | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ble + Cis + Ifo | Ble + Cis + MitoC + Vbl | Ble + Cis + Vbl | Ble + Cis + Vcr | Cis | Cis + Doc | Cis + Epi | Cis + Flu | Cis + Flu + Hyd | Cis + Ifo | Cis + Ifo + Pac | Cis + Metho- trexate | Cis + Mito- lactol | Cis + Pac | Cis + Topo- tecan | Cis + Vcr | Epi | Flu | Flu + MitoC | Hyd | MitoC | Placebo | ||
| 1-year OS | Ble + Cis + Ifo | Ble + Cis + Ifo | 1.11 (0.46, 2.69) | 1.53 (0.61, 3.85) | 1.09 (0.6, 1.96) | 1.6 (0.34, 7.59) | 1.92 (0.66, 5.53) | 0.96 (0.5, 1.86) | 0.98 (0.28, 3.36) | 0.97 (0.59, 1.57) | 1 (0.35, 2.87) | 1.32 (0.54, 3.19) | 1.23 (0.57, 2.64) | 1.12 (0.49, 2.57) | 1.21 (0.55, 2.62) | 1.59 (0.56, 4.52) | 1.09 (0.46, 2.54) | 1.36 (0.64, 2.89) | 1.2 (0.4, 3.63) | 1.09 (0.51, 2.29) | 0.97 (0.37, 2.54) | 1.43 (0.78, 2.62) | |
| Ble + Cis + MitoC + Vbl | 0.67 (0.2, 2.22) | Ble + Cis + MitoC + Vbl | |||||||||||||||||||||
| Ble + Cis + Vbl | 0.88 (0.26, 2.95) | 1.31 (0.34, 4.95) | Ble + Cis + Vbl | 1.38 (0.53, 3.56) | 0.98 (0.48, 2) | 1.44 (0.29, 7.19) | 1.72 (0.58, 5.1) | 0.86 (0.42, 1.77) | 0.88 (0.25, 3.13) | 0.87 (0.38, 2) | 0.9 (0.25, 3.15) | 1.18 (0.47, 2.96) | 1.1 (0.46, 2.63) | 1.01 (0.4, 2.54) | 1.08 (0.45, 2.61) | 1.43 (0.49, 4.17) | 0.98 (0.4, 2.36) | 1.23 (0.54, 2.79) | 1.08 (0.35, 3.35) | 0.98 (0.44, 2.18) | 0.87 (0.33, 2.35) | 1.29 (0.67, 2.46) | |
| Ble + Cis + Vcr | 1.26 (0.26, 6.13) | 1.87 (0.35, 10.02) | 1.43 (0.27, 7.75) | Ble + Cis + Vcr | 0.71 (0.33, 1.52) | 1.04 (0.2, 5.33) | 1.25 (0.41, 3.82) | 0.63 (0.29, 1.34) | 0.64 (0.17, 2.33) | 0.63 (0.26, 1.51) | 0.65 (0.18, 2.34) | 0.86 (0.33, 2.22) | 0.8 (0.32, 1.98) | 0.73 (0.28, 1.91) | 0.79 (0.32, 1.96) | 1.04 (0.34, 3.12) | 0.71 (0.28, 1.78) | 0.89 (0.38, 2.11) | 0.78 (0.25, 2.5) | 0.71 (0.31, 1.65) | 0.63 (0.23, 1.76) | 0.93 (0.47, 1.87) | |
| Cis | 0.88 (0.41, 1.88) | 1.3 (0.48, 3.53) | 1 (0.36, 2.75) | 0.7 (0.17, 2.92) | Cis | 1.47 (0.35, 6.22) | 1.76 (0.7, 4.45) | 0.88 (0.6, 1.3) | 0.9 (0.3, 2.73) | 0.89 (0.56, 1.42) | 0.92 (0.32, 2.62) | 1.21 (0.59, 2.48) | 1.13 (0.7, 1.84) | 1.03 (0.57, 1.85) | 1.11 (0.67, 1.84) | 1.46 (0.59, 3.62) | 1 (0.51, 1.96) | 1.26 (0.76, 2.08) | 1.11 (0.42, 2.94) | 1 (0.6, 1.67) | 0.9 (0.4, 2.01) | 1.32 (0.97, 1.79) | |
| Cis + Doc | 1.02 (0.18, 5.72) | 1.51 (0.24, 9.52) | 1.16 (0.18, 7.35) | 0.81 (0.1, 6.66) | 1.16 (0.25, 5.45) | Cis + Doc | 1.2 (0.22, 6.65) | 0.6 (0.14, 2.67) | 0.61 (0.1, 3.77) | 0.61 (0.13, 2.76) | 0.62 (0.1, 3.71) | 0.82 (0.16, 4.12) | 0.77 (0.17, 3.52) | 0.7 (0.15, 3.32) | 0.75 (0.16, 3.48) | 0.99 (0.18, 5.46) | 0.68 (0.14, 3.34) | 0.85 (0.19, 3.93) | 0.75 (0.13, 4.29) | 0.68 (0.15, 3.14) | 0.61 (0.12, 3.18) | 0.9 (0.2, 3.91) | |
| Cis + Epi | 0.83 (0.26, 2.58) | 1.23 (0.34, 4.36) | 0.94 (0.26, 3.39) | 0.65 (0.13, 3.36) | 0.94 (0.37, 2.38) | 0.81 (0.13, 4.91) | Cis + Epi | 0.5 (0.2, 1.26) | 0.51 (0.13, 2.06) | 0.5 (0.18, 1.4) | 0.52 (0.13, 2.08) | 0.69 (0.23, 2.03) | 0.64 (0.23, 1.82) | 0.58 (0.2, 1.74) | 0.63 (0.22, 1.8) | 0.83 (0.24, 2.8) | 0.57 (0.2, 1.63) | 0.71 (0.26, 1.95) | 0.63 (0.18, 2.24) | 0.57 (0.21, 1.53) | 0.51 (0.16, 1.6) | 0.75 (0.31, 1.78) | |
| Cis + Flu | 0.93 (0.41, 2.11) | 1.39 (0.51, 3.78) | 1.06 (0.38, 2.95) | 0.74 (0.18, 3.12) | 1.06 (0.69, 1.64) | 0.92 (0.18, 4.55) | 1.13 (0.44, 2.89) | Cis + Flu | 1.02 (0.34, 3.09) | 1.01 (0.56, 1.8) | 1.04 (0.34, 3.14) | 1.37 (0.67, 2.81) | 1.28 (0.69, 2.38) | 1.17 (0.58, 2.35) | 1.26 (0.67, 2.37) | 1.65 (0.67, 4.1) | 1.13 (0.58, 2.22) | 1.42 (0.8, 2.52) | 1.25 (0.47, 3.33) | 1.13 (0.68, 1.89) | 1.01 (0.45, 2.27) | 1.49 (1.1, 2.03) | |
| Cis + Flu + Hyd | 0.69 (0.19, 2.51) | 1.02 (0.25, 4.22) | 0.78 (0.19, 3.27) | 0.54 (0.09, 3.15) | 0.78 (0.26, 2.35) | 0.67 (0.1, 4.48) | 0.83 (0.21, 3.29) | 0.74 (0.24, 2.22) | Cis + Flu + Hyd | 0.99 (0.3, 3.26) | 1.02 (0.22, 4.66) | 1.35 (0.38, 4.79) | 1.26 (0.37, 4.22) | 1.15 (0.33, 4.02) | 1.23 (0.36, 4.18) | 1.62 (0.41, 6.49) | 1.11 (0.32, 3.86) | 1.4 (0.42, 4.6) | 1.23 (0.29, 5.15) | 1.11 (0.42, 2.97) | 1 (0.27, 3.73) | 1.46 (0.49, 4.36) | |
| Cis + Ifo | 0.79 (0.4, 1.58) | 1.17 (0.36, 3.84) | 0.9 (0.27, 2.98) | 0.63 (0.13, 3.02) | 0.9 (0.45, 1.81) | 0.77 (0.14, 4.22) | 0.96 (0.31, 2.96) | 0.85 (0.38, 1.86) | 1.15 (0.32, 4.15) | Cis + Ifo | 1.03 (0.4, 2.64) | 1.36 (0.59, 3.13) | 1.27 (0.65, 2.49) | 1.16 (0.55, 2.45) | 1.25 (0.63, 2.48) | 1.64 (0.6, 4.48) | 1.12 (0.51, 2.5) | 1.41 (0.72, 2.77) | 1.24 (0.43, 3.61) | 1.12 (0.57, 2.21) | 1.01 (0.4, 2.51) | 1.48 (0.87, 2.51) | |
| Cis + Ifo + Pac | 0.8 (0.25, 2.53) | 1.18 (0.26, 5.32) | 0.91 (0.2, 4.12) | 0.63 (0.1, 3.91) | 0.91 (0.29, 2.89) | 0.78 (0.11, 5.39) | 0.97 (0.22, 4.16) | 0.85 (0.25, 2.88) | 1.16 (0.24, 5.64) | 1.01 (0.4, 2.54) | Cis + Ifo + Pac | 1.32 (0.38, 4.64) | 1.23 (0.39, 3.92) | 1.12 (0.34, 3.74) | 1.21 (0.38, 3.88) | 1.59 (0.4, 6.3) | 1.09 (0.32, 3.74) | 1.37 (0.43, 4.36) | 1.21 (0.29, 5) | 1.09 (0.34, 3.47) | 0.98 (0.26, 3.62) | 1.44 (0.49, 4.22) | |
| Cis + Metho- trexate | 1 (0.35, 2.85) | 1.48 (0.45, 4.86) | 1.14 (0.34, 3.78) | 0.79 (0.16, 3.82) | 1.14 (0.51, 2.57) | 0.98 (0.17, 5.61) | 1.21 (0.39, 3.75) | 1.07 (0.47, 2.44) | 1.46 (0.4, 5.33) | 1.27 (0.45, 3.57) | 1.25 (0.31, 5.02) | Cis + Metho- trexate | 0.93 (0.39, 2.22) | 0.85 (0.34, 2.15) | 0.92 (0.38, 2.2) | 1.21 (0.41, 3.52) | 0.83 (0.34, 1.99) | 1.04 (0.46, 2.36) | 0.91 (0.29, 2.83) | 0.83 (0.37, 1.84) | 0.74 (0.28, 1.98) | 1.09 (0.57, 2.08) | |
| Cis + Mito- lactol | 1.01 (0.34, 3.03) | 1.5 (0.42, 5.34) | 1.15 (0.32, 4.14) | 0.8 (0.16, 4.11) | 1.15 (0.52, 2.53) | 0.99 (0.17, 5.6) | 1.22 (0.36, 4.14) | 1.08 (0.44, 2.66) | 1.47 (0.38, 5.69) | 1.28 (0.44, 3.67) | 1.27 (0.31, 5.14) | 1.01 (0.33, 3.13) | Cis + Mito- lactol | 0.91 (0.43, 1.95) | 0.98 (0.49, 1.98) | 1.29 (0.46, 3.62) | 0.89 (0.39, 2.03) | 1.11 (0.55, 2.24) | 0.98 (0.33, 2.92) | 0.88 (0.44, 1.8) | 0.79 (0.31, 2.03) | 1.17 (0.66, 2.07) | |
| Cis + Pac | 1.05 (0.44, 2.55) | 1.56 (0.52, 4.66) | 1.2 (0.39, 3.63) | 0.83 (0.19, 3.75) | 1.2 (0.77, 1.88) | 1.03 (0.21, 5.16) | 1.28 (0.45, 3.58) | 1.13 (0.6, 2.11) | 1.53 (0.47, 5.04) | 1.33 (0.58, 3.06) | 1.32 (0.38, 4.57) | 1.05 (0.42, 2.67) | 1.04 (0.42, 2.59) | Cis + Pac | 1.08 (0.5, 2.34) | 1.42 (0.48, 4.18) | 0.97 (0.4, 2.37) | 1.22 (0.56, 2.64) | 1.07 (0.34, 3.36) | 0.97 (0.44, 2.12) | 0.87 (0.32, 2.36) | 1.28 (0.66, 2.48) | |
| Cis + Topo- tecan | 1.03 (0.36, 2.93) | 1.52 (0.45, 5.2) | 1.17 (0.34, 4.04) | 0.81 (0.16, 4.05) | 1.17 (0.57, 2.4) | 1.01 (0.18, 5.52) | 1.24 (0.38, 4.02) | 1.1 (0.48, 2.54) | 1.5 (0.4, 5.56) | 1.3 (0.48, 3.54) | 1.29 (0.33, 5.02) | 1.03 (0.35, 3.04) | 1.02 (0.35, 2.95) | 0.97 (0.42, 2.27) | Cis + Topo- tecan | 1.32 (0.47, 3.72) | 0.9 (0.39, 2.09) | 1.13 (0.55, 2.31) | 1 (0.33, 2.99) | 0.9 (0.44, 1.85) | 0.81 (0.31, 2.09) | 1.19 (0.66, 2.14) | |
| Cis + Vcr | 0.95 (0.27, 3.27) | 1.4 (0.36, 5.47) | 1.07 (0.27, 4.24) | 0.75 (0.14, 4.13) | 1.08 (0.38, 3.08) | 0.93 (0.14, 6) | 1.14 (0.31, 4.25) | 1.01 (0.35, 2.91) | 1.38 (0.32, 5.92) | 1.2 (0.35, 4.1) | 1.18 (0.25, 5.52) | 0.95 (0.28, 3.24) | 0.94 (0.25, 3.48) | 0.9 (0.29, 2.81) | 0.92 (0.26, 3.28) | Cis + Vcr | 0.68 (0.24, 1.94) | 0.86 (0.32, 2.32) | 0.76 (0.21, 2.67) | 0.68 (0.26, 1.81) | 0.61 (0.2, 1.9) | 0.9 (0.38, 2.11) | |
| Epi | 0.87 (0.21, 3.68) | 1.29 (0.27, 6.07) | 0.99 (0.21, 4.7) | 0.69 (0.11, 4.43) | 0.99 (0.27, 3.57) | 0.85 (0.11, 6.34) | 1.05 (0.23, 4.74) | 0.93 (0.26, 3.38) | 1.27 (0.25, 6.49) | 1.1 (0.26, 4.63) | 1.09 (0.2, 6) | 0.87 (0.21, 3.66) | 0.86 (0.19, 3.89) | 0.83 (0.21, 3.22) | 0.85 (0.19, 3.68) | 0.92 (0.19, 4.48) | Epi | 1.26 (0.57, 2.75) | 1.11 (0.37, 3.33) | 1 (0.47, 2.14) | 0.89 (0.34, 2.33) | 1.32 (0.72, 2.39) | |
| Flu | 1.18 (0.47, 2.97) | 1.75 (0.58, 5.3) | 1.34 (0.44, 4.13) | 0.94 (0.21, 4.25) | 1.35 (0.77, 2.36) | 1.16 (0.22, 5.99) | 1.43 (0.5, 4.08) | 1.26 (0.65, 2.47) | 1.72 (0.51, 5.77) | 1.49 (0.62, 3.62) | 1.48 (0.41, 5.31) | 1.18 (0.46, 3.04) | 1.17 (0.44, 3.08) | 1.12 (0.55, 2.31) | 1.15 (0.46, 2.86) | 1.25 (0.39, 3.97) | 1.36 (0.34, 5.35) | Flu | 0.88 (0.31, 2.53) | 0.8 (0.41, 1.56) | 0.71 (0.29, 1.75) | 1.05 (0.63, 1.74) | |
| Flu + MitoC | 0.98 (0.29, 3.31) | 1.45 (0.38, 5.55) | 1.11 (0.29, 4.31) | 0.77 (0.14, 4.21) | 1.11 (0.4, 3.11) | 0.96 (0.15, 6.12) | 1.18 (0.33, 4.31) | 1.05 (0.37, 2.94) | 1.42 (0.34, 6.02) | 1.24 (0.37, 4.16) | 1.23 (0.27, 5.62) | 0.98 (0.29, 3.29) | 0.97 (0.27, 3.53) | 0.93 (0.3, 2.85) | 0.95 (0.27, 3.33) | 1.03 (0.26, 4.12) | 1.12 (0.23, 5.39) | 0.83 (0.27, 2.57) | Flu + MitoC | 0.9 (0.32, 2.56) | 0.81 (0.25, 2.66) | 1.19 (0.47, 3.01) | |
| Hyd | 0.76 (0.33, 1.78) | 1.13 (0.41, 3.16) | 0.87 (0.31, 2.46) | 0.6 (0.14, 2.59) | 0.87 (0.53, 1.43) | 0.75 (0.15, 3.78) | 0.92 (0.35, 2.41) | 0.82 (0.49, 1.35) | 1.11 (0.42, 2.97) | 0.97 (0.42, 2.2) | 0.96 (0.28, 3.29) | 0.76 (0.33, 1.78) | 0.76 (0.3, 1.92) | 0.72 (0.37, 1.41) | 0.74 (0.31, 1.77) | 0.81 (0.27, 2.37) | 0.88 (0.24, 3.24) | 0.65 (0.32, 1.31) | 0.78 (0.27, 2.24) | Hyd | 0.9 (0.37, 2.17) | 1.32 (0.82, 2.12) | |
| MitoC | 0.84 (0.26, 2.68) | 1.24 (0.34, 4.52) | 0.95 (0.26, 3.51) | 0.66 (0.13, 3.46) | 0.95 (0.37, 2.49) | 0.82 (0.13, 5.05) | 1.01 (0.29, 3.5) | 0.9 (0.34, 2.36) | 1.22 (0.3, 4.91) | 1.06 (0.33, 3.36) | 1.05 (0.24, 4.6) | 0.84 (0.26, 2.66) | 0.83 (0.24, 2.87) | 0.79 (0.28, 2.29) | 0.81 (0.25, 2.7) | 0.89 (0.23, 3.36) | 0.96 (0.21, 4.42) | 0.71 (0.24, 2.07) | 0.86 (0.23, 3.19) | 1.1 (0.41, 2.95) | MitoC | 1.47 (0.7, 3.1) | |
| Placebo | 1.09 (0.52, 2.29) | 1.61 (0.63, 4.1) | 1.23 (0.48, 3.2) | 0.86 (0.21, 3.46) | 1.24 (0.87, 1.76) | 1.06 (0.22, 5.19) | 1.32 (0.56, 3.11) | 1.16 (0.8, 1.68) | 1.58 (0.54, 4.62) | 1.38 (0.66, 2.86) | 1.36 (0.42, 4.42) | 1.09 (0.52, 2.26) | 1.08 (0.45, 2.55) | 1.03 (0.58, 1.82) | 1.06 (0.48, 2.35) | 1.15 (0.43, 3.09) | 1.25 (0.36, 4.3) | 0.92 (0.51, 1.67) | 1.11 (0.42, 2.91) | 1.42 (0.93, 2.18) | 1.3 (0.53, 3.17) | Placebo | |