Table 4. Mixed evidence of 5-year overall survival and recurrence-free survival for different treatments.
| 5-year RFS | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ble + Cis + Ifo | Ble + Cis + MitoC + Vbl | Ble + Cis + Vbl | Ble + Cis + Vcr | Cis | Cis + Doc | Cis + Epi | Cis + Flu | Cis + Flu + Hyd | Cis + Metho- trexate | Cis + Vcr | Epi | Flu | Flu + MitoC | Hyd | MitoC | Placebo | ||
| 5-year OS | Ble + Cis + Ifo | Ble + Cis + Ifo | ||||||||||||||||
| Ble + Cis + MitoC + Vbl | 0.72 (0.28, 1.85) | Ble + Cis + MitoC + Vbl | ||||||||||||||||
| Ble + Cis + Vbl | 1.3 (0.53, 3.2) | 1.79 (0.59, 5.42) | Ble + Cis + Vbl | 1.05 (0.5, 2.22) | 0.92 (0.49, 1.72) | 0.59 (0.26, 1.32) | 1.48 (0.69, 3.16) | 0.81 (0.43, 1.51) | 0.66 (0.3, 1.44) | 0.95 (0.46, 1.95) | 1.14 (0.52, 2.47) | 1.02 (0.32, 3.23) | 1.04 (0.55, 1.98) | 0.82 (0.41, 1.65) | 1.04 (0.54, 2.01) | 0.47 (0.21, 1.07) | 1.18 (0.66, 2.12) | |
| Ble + Cis + Vcr | 3.03 (0.99, 9.32) | 4.19 (1.15, 15.24) | 2.34 (0.66, 8.29) | Ble + Cis + Vcr | 0.87 (0.52, 1.48) | 0.56 (0.27, 1.16) | 1.41 (0.72, 2.76) | 0.77 (0.46, 1.29) | 0.62 (0.31, 1.26) | 0.9 (0.48, 1.69) | 1.08 (0.54, 2.16) | 0.97 (0.32, 2.91) | 0.99 (0.57, 1.7) | 0.78 (0.42, 1.43) | 0.99 (0.56, 1.73) | 0.45 (0.21, 0.94) | 1.12 (0.71, 1.79) | |
| Cis | 0.8 (0.47, 1.36) | 1.1 (0.48, 2.53) | 0.62 (0.28, 1.36) | 0.26 (0.09, 0.74) | Cis | 0.64 (0.39, 1.06) | 1.61 (0.94, 2.76) | 0.88 (0.65, 1.19) | 0.71 (0.41, 1.24) | 1.03 (0.63, 1.68) | 1.24 (0.7, 2.18) | 1.11 (0.4, 3.09) | 1.13 (0.83, 1.53) | 0.89 (0.56, 1.4) | 1.13 (0.8, 1.6) | 0.51 (0.28, 0.96) | 1.29 (1.01, 1.63) | |
| Cis + Doc | 0.52 (0.25, 1.09) | 0.72 (0.27, 1.9) | 0.4 (0.16, 1.03) | 0.17 (0.05, 0.54) | 0.65 (0.39, 1.08) | Cis + Doc | 2.51 (1.2, 5.24) | 1.37 (0.77, 2.46) | 1.11 (0.53, 2.35) | 1.61 (0.8, 3.23) | 1.93 (0.9, 4.1) | 1.73 (0.55, 5.41) | 1.76 (0.98, 3.16) | 1.38 (0.7, 2.73) | 1.76 (0.96, 3.24) | 0.8 (0.36, 1.78) | 2.01 (1.15, 3.49) | |
| Cis + Epi | 1.18 (0.6, 2.33) | 1.63 (0.64, 4.15) | 0.91 (0.37, 2.24) | 0.39 (0.13, 1.19) | 1.48 (0.88, 2.51) | 2.28 (1.1, 4.75) | Cis + Epi | 0.55 (0.32, 0.94) | 0.44 (0.22, 0.91) | 0.64 (0.33, 1.22) | 0.77 (0.38, 1.56) | 0.69 (0.23, 2.09) | 0.7 (0.4, 1.23) | 0.55 (0.3, 1.03) | 0.7 (0.39, 1.25) | 0.32 (0.15, 0.68) | 0.8 (0.49, 1.3) | |
| Cis + Flu | 0.89 (0.53, 1.5) | 1.23 (0.54, 2.81) | 0.69 (0.31, 1.51) | 0.29 (0.1, 0.82) | 1.11 (0.85, 1.46) | 1.71 (0.96, 3.06) | 0.75 (0.45, 1.26) | Cis + Flu | 0.81 (0.47, 1.39) | 1.17 (0.72, 1.89) | 1.4 (0.8, 2.46) | 1.26 (0.45, 3.5) | 1.28 (0.91, 1.81) | 1.01 (0.64, 1.58) | 1.28 (0.93, 1.77) | 0.58 (0.32, 1.08) | 1.46 (1.17, 1.83) | |
| Cis + Flu + Hyd | 0.64 (0.33, 1.23) | 0.88 (0.35, 2.21) | 0.49 (0.2, 1.19) | 0.21 (0.07, 0.64) | 0.79 (0.5, 1.27) | 1.22 (0.61, 2.45) | 0.54 (0.28, 1.04) | 0.71 (0.45, 1.13) | Cis + Flu + Hyd | 1.44 (0.73, 2.86) | 1.73 (0.83, 3.64) | 1.55 (0.5, 4.82) | 1.58 (0.88, 2.86) | 1.25 (0.64, 2.41) | 1.59 (1.03, 2.45) | 0.72 (0.33, 1.58) | 1.81 (1.06, 3.08) | |
| Cis + Metho- trexate | 0.95 (0.51, 1.78) | 1.32 (0.54, 3.22) | 0.73 (0.31, 1.73) | 0.31 (0.11, 0.93) | 1.19 (0.76, 1.88) | 1.84 (0.93, 3.64) | 0.81 (0.43, 1.49) | 1.07 (0.69, 1.67) | 1.5 (0.82, 2.74) | Cis + Metho- trexate | 1.2 (0.61, 2.34) | 1.07 (0.36, 3.19) | 1.1 (0.66, 1.82) | 0.86 (0.48, 1.54) | 1.1 (0.65, 1.86) | 0.5 (0.24, 1.02) | 1.25 (0.82, 1.92) | |
| Cis + Vcr | 1.26 (0.65, 2.48) | 1.75 (0.69, 4.42) | 0.97 (0.4, 2.38) | 0.42 (0.14, 1.27) | 1.58 (0.94, 2.66) | 2.44 (1.18, 5.05) | 1.07 (0.55, 2.08) | 1.42 (0.85, 2.37) | 1.99 (1.04, 3.83) | 1.33 (0.72, 2.44) | Cis + Vcr | 0.9 (0.29, 2.76) | 0.91 (0.51, 1.64) | 0.72 (0.38, 1.37) | 0.92 (0.5, 1.67) | 0.42 (0.19, 0.9) | 1.04 (0.62, 1.74) | |
| Epi | 0.92 (0.43, 1.96) | 1.27 (0.47, 3.42) | 0.71 (0.27, 1.85) | 0.3 (0.09, 0.97) | 1.15 (0.62, 2.14) | 1.77 (0.79, 3.97) | 0.78 (0.37, 1.65) | 1.03 (0.56, 1.91) | 1.45 (0.69, 3.03) | 0.96 (0.48, 1.95) | 0.73 (0.34, 1.53) | Epi | 1.02 (0.36, 2.88) | 0.8 (0.27, 2.35) | 1.02 (0.36, 2.91) | 0.47 (0.15, 1.47) | 1.16 (0.43, 3.16) | |
| Flu | 0.95 (0.52, 1.71) | 1.31 (0.55, 3.12) | 0.73 (0.32, 1.68) | 0.31 (0.11, 0.91) | 1.18 (0.85, 1.64) | 1.82 (0.99, 3.35) | 0.8 (0.44, 1.44) | 1.06 (0.72, 1.56) | 1.49 (0.86, 2.58) | 0.99 (0.59, 1.67) | 0.75 (0.42, 1.34) | 1.03 (0.52, 2.02) | Flu | 0.79 (0.49, 1.27) | 1 (0.67, 1.5) | 0.46 (0.24, 0.86) | 1.14 (0.86, 1.5) | |
| Flu + MitoC | 0.69 (0.35, 1.37) | 0.95 (0.37, 2.43) | 0.53 (0.22, 1.31) | 0.23 (0.07, 0.7) | 0.86 (0.51, 1.47) | 1.33 (0.63, 2.79) | 0.58 (0.29, 1.15) | 0.78 (0.46, 1.31) | 1.09 (0.56, 2.12) | 0.72 (0.39, 1.35) | 0.55 (0.28, 1.07) | 0.75 (0.35, 1.6) | 0.73 (0.4, 1.32) | Flu + MitoC | 1.27 (0.77, 2.1) | 0.58 (0.29, 1.16) | 1.45 (0.98, 2.14) | |
| Hyd | 0.98 (0.57, 1.69) | 1.35 (0.58, 3.13) | 0.75 (0.34, 1.68) | 0.32 (0.11, 0.91) | 1.22 (0.93, 1.6) | 1.88 (1.06, 3.36) | 0.83 (0.48, 1.42) | 1.1 (0.84, 1.43) | 1.54 (1.05, 2.25) | 1.02 (0.64, 1.64) | 0.77 (0.45, 1.32) | 1.06 (0.56, 2) | 1.03 (0.69, 1.53) | 1.42 (0.82, 2.45) | Hyd | 0.46 (0.24, 0.87) | 1.14 (0.83, 1.55) | |
| MitoC | 0.74 (0.34, 1.59) | 1.02 (0.37, 2.77) | 0.57 (0.21, 1.5) | 0.24 (0.07, 0.79) | 0.92 (0.48, 1.75) | 1.42 (0.62, 3.22) | 0.62 (0.29, 1.34) | 0.83 (0.44, 1.56) | 1.16 (0.54, 2.47) | 0.77 (0.38, 1.58) | 0.58 (0.27, 1.25) | 0.8 (0.35, 1.85) | 0.78 (0.39, 1.55) | 1.07 (0.49, 2.32) | 0.75 (0.39, 1.45) | MitoC | 2.5 (1.41, 4.43) | |
| Placebo | 1.15 (0.71, 1.86) | 1.59 (0.71, 3.54) | 0.88 (0.41, 1.89) | 0.38 (0.14, 1.04) | 1.44 (1.15, 1.8) | 2.22 (1.27, 3.87) | 0.97 (0.6, 1.56) | 1.29 (1.05, 1.59) | 1.81 (1.15, 2.86) | 1.2 (0.81, 1.79) | 0.91 (0.57, 1.45) | 1.25 (0.7, 2.24) | 1.21 (0.86, 1.71) | 1.67 (1.02, 2.71) | 1.18 (0.91, 1.52) | 1.56 (0.85, 2.86) | Placebo | |