Figure 4. The expression of IRF8 increased in tumor tissues from DLBCL patients.

(A) IRF8 was expressed in the nucleus of lymphocytes in benign lymphoid tissue, and it was highly expressed in the germinal center of lymphoid follicles (×40). (B) Graph of IRF8 relative expression (relative IOD) in IHC from tumor tissues (n=48) and benign tissues (n=18). (C) Immunohistochemical staining showed various intensities of IRF8 expression in the nucleus of tumor cells or tumor-infiltrating lymphocytes (×40). (D) Graph of relative IRF8 transcriptional level in tumor tissues (n=48) and benign tissues (n=18). Error bars represent SD. Significance was determined using independent-sample Student's t/t′ test. The P value is indicated in each graph.