Table 2. Levels (AUC) of discriminant metabolites in EBC clusters LR-1, LR-2 and LR-3.
| METABOLITES | δ1H (ppm)a | VIP value | AUC (LR-1)b | AUC (LR-2)b | AUC (LR-3)b | p valuec |
|---|---|---|---|---|---|---|
| CARBOHYDRATES | ||||||
| LACTATE | 1.32 | 13.76 | 11.31 (10.8–11.89) | 7.91* (6.72–8.54) | 5.87*$ (5.51–6.33) | < 0 .001 |
| PYRUVATE | 2.36 | 2.02 | 0.50 (0.45–0.56) | 0.36* (0.3–0 .41) | 0.34* (0.31–0.36) | < 0.001 |
| GLUCOSE | 3.76 | 2.55 | 2.90 (2.7–3.09) | 3.23 (3.03–3.29) | 2.98 (2.75–3.13) | 0.008 |
| CETONIC BODIES | ||||||
| ACETATE | 1.92 | 1.65 | 0.19 (0.17–0.22) | 0.18 (O.13–0.19) | 0.21 (0.18–0.24) | 0.025 |
| ACETO-ACETATE | 2.28 | 1.50 | 0.13 (011–0.16) | 0.12 (0.09–0.21) | 0.16 (0.12–0.26) | 0.20 |
| 3-HX-BUTYRATE | 4.16 | 1.48 | 0.18 (0.14–0.32) | 0.20 (015–0.35) | 0.22 (0.11–0.67) | 0.92 |
| AMINO ACIDS | ||||||
| ALANINE | 1.46 | 0.98 | 1.95 (1.78–2 .29) | 1.56 (1.44–1.87) | 1.60 (1.55–2.05) | 0.026 |
| GLUTAMINE | 2.42 | 1.20 | 1.50 (1.44–1.53) | 1.48 (1.31–1.58) | 1.68$ (1.59–1.78) | 0.003 |
| GLUTAMATE | 2.00 | 1.12 | 0.43 (0.35–0.52) | 0.32 (0.27–0.39) | 0.48 (0.29–0.65) | 0.15 |
| LEUCINE | 0.96 | 1.33 | 0.86 (0.77–1.09) | 0.93 (0.78–1.04) | 1.00 (0.89–1.07) | 0.43 |
| VALINE | 0.98 | 0.95 | 0.93 (0.77–1.04) | 0.87 (0.74–0.99) | 0.89 (0.82–1.05) | 0.75 |
| GLYCINE | 3.56 | 1.28 | 0.66 (0.58–0.86) | 0.66 (0.48–0.80) | 0.71 (0.49–0.95) | 0.48 |
| UREA METABOLITES | ||||||
| UREA | 5.79 | 1.05 | 0.25 (0.19–0.47) | 0.33 (026–0.66) | 0.49 (0.32–0.96) | 0.30 |
| CREATININE | 4.06 | 1.6 | 0.21 (0.19–0.23) | 0.22 (0.19–0.25) | 0.26 (0.23–0.3) | 0.07 |
| CREATINE | 3.94 | 1.41 | 0.24 (0.21–0.29) | 0.23 (0.16–0.28) | 0.29 (0.23–0.33) | 0.18 |
A: Chemical shift
B: Area Under the Curve (AUC): median (25%–75%).
C: Kruskal-Wallis One Way Analysis of Variance on Ranks and if significant Pairwise Multiple Comparison Procedures (Tukey test): After Bonferroni correction significant p level value < 0.003(*: significant compared to LR-1; $: significant compared to LR-2).