. 2017 Jun 6;8(30):49973–49987. doi: 10.18632/oncotarget.18385

Table 1. Summary of results of growth inhibition assays upon drug exposure for 48h.

Cell line	Tubulysin B EC1009			Tubulysin B hydrazide EC0347			Tubulysin B bis ether EC1820
Cell line	IC₅₀, nM	S.D.	Fold resistance	IC₅₀, nM	S.D.	Fold resistance	IC₅₀, nM	S.D.	Fold resistance
A549	1.96	0.01	1.00	1.83	0.04	1.00	0.47	0.04	1.00
A549+Ko143	2.11	0.06	1.07	1.91	0.13	1.04^a	0.37	0.01	0.78
A549/K1.5	2.49	0.12	1.27	2.33	0.18	1.27	0.64	0.02	1.38
A549/K1.5+Ko143	2.00	0.02	1.02^a	2.26	0.15	1.24	0.69	0.00	1.48
KB-3-1	1.08	0.04	1.00	0.85	0.09	1.00	0.28	0.07	1.00
KB-3-1+TQD	1.08	0.11	1.00^a	0.84	0.05	0.99^a	0.27	0.05	0.98^a
KB-V1	6.55	1.06	6.06	177.05	23.00	209.11	8.09	0.82	29.24
KB-V1+TQD	1.16	0.07	1.07^a	1.11	0.14	1.31	0.28	0.02	1.01^a
2008 WT	0.92	0.05	1.00	1.94	0.11	1.00	0.27	0.02	1.00
2008 WT+MK571	0.70	0.06	0.76	0.45	0.06	0.23	0.07	0.01	0.26
2008/MRP1	2.33	0.09	2.54	16.59	0.43	8.57	2.35	0.03	8.85
2008/MRP1+MK571	0.97	0.03	1.05^a	1.97	0.16	1.01^a	0.30	0.01	1.11

All differences shown as fold of resistance have a P-value<0.05 excluding those indicated by an ^a.