Table 2. Summary of results of growth inhibition assays upon drug exposure for 4h.
| Cell line | Tubulysin B EC1009 | Tubulysin B hydrazide EC0347 | Tubulysin B bis ether EC1820 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| IC50, nM | S.D. | Fold resistance | IC50, nM | S.D. | Fold resistance | IC50, nM | S.D. | Fold resistance | |
| KB-3-1 | 10.42 | 0.11 | 1.00 | 4.31 | 0.38 | 1.00 | 1.35 | 0.06 | 1.00 |
| KB-V1 | 38.67 | 2.58 | 3.71 | 4,616.0 | 114.00 | 1,072.2 | 183.83 | 43.38 | 136.17 |
| KB-V1+TQD | 16.67 | 1.97 | 1.60 | 6.99 | 0.41 | 1.62 | 2.06 | 0.08 | 1.52 |
| KB-V1-VBT | 134.21 | 0.44 | 12.89 | 26,327.0 | 212.85 | 6,115.5 | 1,595.2 | 140.30 | 1,181.6 |
| KB-V1-VBT+TQD | 24.21 | 0.19 | 2.32 | 7.69 | 1.44 | 1.79 | 4.27 | 1.81 | 3.16 |
All differences shown as fold of resistance have a P-value ≤0.026.