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. 2017 Apr 20;8(30):50034–50050. doi: 10.18632/oncotarget.17293

Table 3. Meta-analysis results for the seven studied polymorphisms and RCC risk.

Genotype comparison OR [95% CI] Heterogeneity-test Model
P for Q test I2(%)
VEGF -2578C/A (1588 cases, 2470 controls)
A vs C (Allele model) 1.30 [1.18, 1.43] 0.689 0 Fixed
AA vs CC (Homozygous model) 1.60 [1.31, 1.96] 0.430 0 Fixed
CA vs CC (Heterozygous model) 1.24 [1.08, 1.43] 0.062 52.4 Fixed
AA+CA vs CC (Dominant model) 1.31 [1.15, 1.50] 0.051 54.5 Fixed
AA vs CA+CC (Recessive model) 1.39 [1.16, 1.67] 0.626 0 Fixed
VEGF +936C/T (1636 cases, 2712 controls)
T vs C (Allele model) 1.16 [1.05,1.29] 0.130 39.3 Fixed
TT vs CC (Homozygous model) 1.33 [1.08, 1.65] 0.236 25.3 Fixed
CT vs CC (Heterozygous model) 1.13 [0.97, 1.30] 0.246 23.9 Fixed
TT+CT vs CC (Dominant model) 1.16 [1.02, 1.33] 0.123 40.2 Fixed
TT vs CT+CC (Recessive model) 1.25 [1.02, 1.52] 0.478 0 Fixed
VEGF +1612G/A (1184 cases, 1862 controls)
A vs G (Allele model) 1.08 [1.00,1.17] 0.639 0 Fixed
AA vs GG (Homozygous model) 1.33 [1.02, 1.74] 0.527 0 Fixed
GA vs GG (Heterozygous model) 1.09 [0.93, 1.27] 0.919 0 Fixed
AA+GA vs GG (Dominant model) 1.12 [0.96, 1.30] 0.760 0 Fixed
AA vs GA+GG (Recessive model) 1.27 [0.99, 1.64] 0.558 0 Fixed
VEGF -634G/C (1229 cases, 2092 controls)
C vs G (Allele model) 1.11 [1.00,1.23] 0.882 0 Fixed
CC vs GG (Homozygous model) 1.22 [0.99, 1.51] 0.964 0 Fixed
GC vs GG (Heterozygous model) 1.13 [0.96, 1.32] 0.998 0 Fixed
CC+GC vs GG (Dominant model) 1.15 [0.99, 1.33] 0.994 0 Fixed
CC vs GC+GG (Recessive model) 1.14 [0.94, 1.38] 0.961 0 Fixed
VEGF +460T/C (677 cases, 1299 controls)
C vs T (Allele model) 0.92 [0.58,1.46] 0.000 87.9 Random
CC vs TT (Homozygous model) 0.88 [0.38, 2.01] 0.006 80.6 Random
TC vs TT (Heterozygous model) 1.12 [0.89, 1.41] 0.235 31 Fixed
CC+TC vs TT (Dominant model) 0.98 [0.61, 1.58] 0.017 75.5 Random
CC vs TC+TT (Recessive model) 1.10 [0.87, 1.39] 0.011 77.9 Random
VEGF +405 G/C (1086 cases, 1460 controls)
C vs G (Allele model) 1.18 [1.05,1.33] 0.113 54.1 Fixed
CC vs GG (Homozygous model) 1.35 [1.06,1.72] 0.125 51.8 Fixed
GC vs GG (Heterozygous model) 1.25 [1.05,1.48] 0.407 0 Fixed
CC+GC vs GG (Dominant model) 1.27 [1.08,1.49] 0.191 39.5 Fixed
CC vs GC+GG (Recessive model) 1.06 [0.84,1.33] 0.628 0 Fixed
VEGF -1154G/A (564 cases, 892 controls)
A vs G (Allele model) 1.04 [0.88,1.24] 0.228 32.3 Fixed
AA vs GG (Homozygous model) 1.07 [0.73,1.57] 0.330 9.7 Fixed
GA vs GG (Heterozygous model) 1.06 [0.84,1.35] 0.392 0 Fixed
AA+GA vs GG (Dominant model) 1.06 [0.84,1.32] 0.266 24.4 Fixed
AA vs GA+GG (Recessive model) 1.04 [0.72,1.51] 0.493 0 Fixed