Table 1. The expression of miR-133b and its related targeting genes involved in human cancer.
| No. | Cancer types | Related gene | Desription | Function | Re. |
|---|---|---|---|---|---|
| 1(+) | Hepatocellular carcinoma | PPP2R2D(−) | one of four isoforms (α, β, γ, and δ) of the protein phosphatase 2A | cell cycle regulation | [65] |
| 2(−) | NSCLC (radioresistant) | PKM2(+) | pyruvate kinase isoform M2 | inhibition of PKM2-mediated glycolysis | [40] |
| 3(−) | Colorectal adenoma and cancer | PTB1;PKM2(+)/PKM1(−) | polypyrimidine tract-binding protein 1; Pyruvate kinase muscle has 2 isoforms | switch their PKM isoform from PKM1 to PKM2 and promotes the Warburg effect | [42] |
| 4(−) | Ovarian cancer(chemotherapy resistance) | GST-π /MDR1(+) | glutathione S-transferase (GST)-π and multidrug resistance protein 1 (MDR1) | reduce ovarian cancer drug resistance | [69] |
| 5(+) | glioblastoma (GMP) | EGFR (−) | epidermal growth factor receptor | microvascular proliferation | [52] |
| 7(−) | Glioblastoma | MMP14)(+) | matrix metalloproteinase 14 | inhibits cell migration and invasion | [56] |
| 8(−) | Ovarian cancer | EGFR(+) | epidermal growth factor receptor | inhibit proliferation and invasion | [44] |
| 9(+) | Cancer associated fibroblasts (CAF) | IL6 (untargeted gene) | interleukin-6 | IL6-HPFs and (cancer associated fibroblasts) CAFs | [62] |
| 10(?) | *DLD-1, #MCF10A cells | DR5(−) | death receptors 5 | induces apoptosis | [18] |
| 11(/) | (HeLa cells)cervical cancer | FAIM/GSTP1 | antiapoptotic protein Fas apoptosis inhibitory molecule/detoxifying protein glutathione-S-transferase pi | induces apoptosis | [19] |
| 12(−) | Androgen-independentprostate cancer | FAIM/GSTP1(+) | antiapoptotic protein Fas apoptosis inhibitory molecule/detoxifying protein glutathione-S-transferase pi | impaired proliferation and cellular metabolic activity and induces apoptosis | [19] |
| 13(−) | Colorectal cancer | c-Met(+) | MET proto-oncogene, receptor tyrosine kinase | effect the proliferation and apoptosis | [33] |
| 14(−) | Squamous cell carcinoma of tongue | PKM2(+) | pyruvate kinase isoform M2 | interfere with the efficiency of proliferation and apoptosis | [43] |
| 15(−) | Lung cancer | MCL-1/ BCL2L2 (BCLw)(+) | members of the B-cell CLL/lymphoma 2 (BCL-2) family of apoptotic molecules | induces apoptosis | [23] |
| 16(−) | ESCC | FSCN1(+) | fascin actin-bundling protein 1 | cell growth and invasion inhibition | [57] |
| 17(+) | Cervical carcinoma | MST2/CDC42/RHOA(−) | mammalian sterile 20-like kinase 2/cell division control protein 42 homolog/ras homolog gene family member A | results in activation of AKT1 and ERK signaling pathways, and promotes both in vivo tumorigenesis and metastasis | [51] |
| 18(−) | Prostate cancer | EGFR(+) | epidermal growth factor receptor | inhibited cell proliferation, migration and invasion | [45] |
| 19(−) | Non-small cell lung cance | EGFR(+) | epidermal growth factor receptor | modulate apoptosis, invasion and sensitivity to EGFR-TKI | [47] |
| 20(−) | Gastrointestinal stromal tumor | FSCN1(+) | fascin actin-bundling protein 1 | tumor size, mitotic counts, risk grade, blood vessel invasion and mucosal ulceration | [58] |
| 21(−) | Bladder cancer | EGRR(+) | epidermal growth factor receptor | inhibits cell proliferation, migration and invasion | [46] |
| 22(−) | Osteosarcoma | MET(+) | MET proto-oncogene, receptor tyrosine kinase | control cell proliferation and cell cycle | [34] |
| 23(−) | Gastric cancer | FGFR1(+) | fibroblast growth factor receptor-like 1 | inhibit cell proliferation and colony formation | [27] |
| 24(+) | Androgen-dependent Pca | CDC2L5, PTPRK, RB1CC1, and CPNE3(−) | encoded CDK13, tyrosine phosphatase (PTP) family, transcription factor termed RB1-inducible coiled-coil 1, calcium-dependent membrane-binding protein termed copine III | promoting cell survival and proliferation, basically required for mediating AR signalling to PCa cell viability and survival | [20] |
| 25(−) | Colorectal cancer | CXCR4(+) | C-X-C motif chemokine receptor 4 | inhibited invasion and stimulated apoptosis | [60] |
| 25(−) | Osteosarcoma | BCL2L2, MCL-1, IGF1R, MET(+) | lymphoma 2 (BCL-2) family of apoptotic molecules, members of the B-cell CLL, insulin like growth factor 1 receptor, MET proto-oncogene, receptor tyrosine kinase | inhibited cell proliferation, invasion and migration, and induced apoptosis | [24] |
| 26(−) | Gastric cancer | Gli1(+) | GLI family zinc finger 1, Zeb2 and OPN are direct transcriptional targets of Gli1 | inhibits cell migration and invasion | [61] |
| 27(−) | Colon cancer | RhoA, TAp63 (untargeted gene)(−) | ras homolog gene family member A, tumor protein p63, microRNA-133b is a transcriptional target of TAp63 | TAp63 inhibits cell migration and invasion through microRNA-133b | [115] |
| 28(+/–) | Prostate cancer | RB1CC1(−) | RB1 inducible coiled-coil 1 | effect the cell proliferation, cell cycle, and apoptosis | [21] |
| 29(−) | Colorectal cancer | TBPL1(+) | TATA-box binding protein like 1 | proliferation | [29] |
| 30(−) | Gastric cancer | Sp1(+) | Sp1 transcription factor | inhibit proliferation, migration, invasion and cell cycle progression | [28] |
| 31(−) | Glioma | hERG, Kv11.1, KCNH2(+) | the human ether-a-go-go-related gene potassium channel | inhibition of proliferation of and induced apoptosis | [30] |
| 32(−) | Bladder cancer | BCL2L2(Bcl-w), Akt1(+) | Bcl-2-like protein 2, serine/threonine kinase 1 | inhibition of proliferation of and induced apoptosis | [25] |
| 33(−) | Gastric cancer | FSCN1(+) | Fascin actin-bundling protein 1 | inhibit cell proliferation, cell migration and invasion | [59] |
| 34(−) | Several human cancer | Nup214(+) | nucleoporin 214 | perturbs mitotic timing and leads to cell death | [32] |
| 35(−) | Colorectal cancer | EGFR | epidermal growth factor receptor | inhibit growth and invasion | [48] |
| 36(−) | Gastric cancer | Mcl-1, Bcl-xL(+) | BCL2 family apoptosis regulator | suppress GC cell proliferation and promote cell apoptosis | [26] |
| 37(−) | Glioma | Sirt1(+) | silent information regulator 1 | reduced the proliferation and invasion | [36] |
| 38(−) | Hepatocellular carcinoma | Sirt1(+) | silent information regulator 1 | regulating HCC cell proliferation, invasion and apoptosis | [35] |
| 39(−) | Nasopharyngeal carcinoma | S1PR1(+) | Sphingosine-1-phosphate receptor 1 | suppresses cell proliferation | [37] |
| 40(−) | Hepatocellular carcinoma | CTGF(+) | Connective tissue growth factor | influences HCC cell proliferation and migration, and ductular reaction (DR)/oval cell (OC) response | [31] |
HPF: human prostate fibroblasts;* DLD-1 cell line, TRAIL-resistant human colon cancer; # MCF10A cells, breast epithelial proliferating; -: decreased expression; +: increase expression. Re.: reference; GMP: Glioblastoma microvascular proliferation; ESCC: Esophageal squamous cell carcinoma