Table 1. miRNAs that target EGFR signaling pathway involved in cancer.

miRNAs	Carcinomas	Biological effect	Regulation	Citations
miR-200	anaplastic thyroid cancer/bladder cancer	Regulate EMT and reverse resistance of EGFR therapy	Down	[65, 66]
miR-23b/27b	bladder cancer	Regulate EGFR and suppress cancer	Down	[55]
miR-27a	renal cell carcinoma	Suppress human RCC cell proliferation and induce cell apoptosis	Down	[56]
miR-133a	NSCLC	Suppresses multiple oncogenic membrane receptors and cell invasion	Down	[57]
miR-134	NSCLC	Inhibit proliferation	Down	[58]
miR-7	various cancer cells	Inhibit EGFR-PI3K-AKT signaling and reverse radio resistance	Down	[67]
miR-34a	solid cancer	Regulate Axl receptor tyrosine kinase by targeting SIRT1 and MEK1	Down	[68]
miR-145	lung cancer	Negatively regulate EGFR expression	Down	[69]
miR-146a	NSCLC	Inhibit EGFR in NSCLC cancer cells	Down	[70, 71]
miR-146b-5p	glioblastoma	Suppress EGFR expression	Down	[72]
miR-206	squamous lung cancer	Suppress EGFR signaling	Down	[73]
miR-135a-1	prostate cancer	Inhibit cell growth and migration	Down	[74]
miR-133a	NSCLC	Suppress EGFR signaling	Down	[57]
miR-133b	NSCLC	Suppress EGFR pathway signaling and enhance susceptibility to EGFR-TKI	Down	[75]
miR-1203,1237,541,542-5p	human lung cancer	Downregulate EGFR	Down	[67, 76]
miR-199a-3p	prostate cancer	Suppress the expansion and tumor	Down	[77]
miR-2861	cervical cancer	Inhibit tumor growth	Down	[78]
miR-25	lung cancer	Upregulate EGFR	Up	[79]
miR-24		Activates EGFR signaling	Up	[80]
miR-21	glioblastoma	Regulate the EGFR/AKT pathway in a PTEN independent manner	Up	[81]