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. 2017 Apr 7;8(30):50240–50251. doi: 10.18632/oncotarget.16933

Figure 1. MiRNAs in PCa pathogenesis.

Figure 1

Schematic representation of prostate cancer pathogenesis and miRNAs involved in this process. Cell cycle block and apoptosis resistance lead to cancer; afterwards, prostate cancer cells are subjected to epithelial mesenchymal transition (EMT), which confers increased migratory capacity and invasiveness to generate metastases. Over-expressed miRNAs are highlighted in red, down-expressed miRNAs are highlighted in green.