Table 3. Mutation profiles of identified top candidate BRCA driver genes.
| BRCA Drivers | Substitution % | InDel % | Amplification % | Copy Gain % | Copy Loss % | Deletion (%) | Expression Outliers High % |
|---|---|---|---|---|---|---|---|
| CDH1* | 3.2 | 0.1 | - | 1.4 | 16.5 | 2.9 | - |
| CBFB^ | 1.7 | - | - | 1 | 16.4 | 1.3 | - |
| CTCF | 1.9 | - | 0.1 | 1.1 | 16 | 2.9 | |
| MAP2K4* | 2.4 | 0.4 | 0.2 | 0.4 | 12.2 | 2.5 | - |
| BCL6B | 0.1 | - | 0.1 | 0.4 | 12.2 | 1.4 | - |
| TP53* | 6.8 | 0.4 | - | 0.6 | 12 | 1.5 | - |
| NCOR1+ | 3 | 0.3 | 0.2 | 0.8 | 11.3 | 1.5 | - |
| PGR | 0.5 | - | 0.2 | 2 | 10.8 | 2.8 | 51.4 |
| RB1* | 1.3 | - | - | 0.8 | 9.3 | 1.8 | - |
| BRCA2* | 1.3 | - | 0.2 | 1.8 | 7.4 | 1.2 | 66.5 |
| MCF2L | 0.5 | - | 0.4 | 4 | 6.7 | 2.5 | - |
| COL4A2 | 0.5 | - | 0.3 | 4.1 | 6.5 | 2 | - |
| GOLGA6L2 | 0.1 | - | 0.3 | 2.2 | 6.2 | 1.7 | - |
| ARID1A* | 1.4 | 0.1 | 0.1 | 0.3 | 5.6 | 0.8 | - |
| SETD2* | 1 | - | - | 0.8 | 5.1 | 0.5 | - |
| PIK3CD | 0.4 | - | 0.2 | 0.8 | 5.1 | 1.2 | 1.2 |
| DNAH12 | 1 | 0.1 | 0.1 | 0.6 | 4.9 | 0.5 | 15.8 |
| FLNB | 1.2 | 0.3 | 0.1 | 0.8 | 4.8 | 0.6 | - |
| ZFP36L1 | 0.5 | 0.1 | 0.1 | 1.4 | 4.7 | 1 | - |
| LAMA1 | 1 | - | 0.1 | 2.7 | 4.3 | 1 | - |
| BRCA1* | 1 | - | 0.2 | 4.7 | 4.2 | 0.1 | 52.2 |
| MAP3K1 | 3.5 | 0.1 | - | 2.2 | 4.1 | 0.8 | - |
| PTEN* | 1.7 | 0.4 | - | 0.7 | 3.9 | 0.9 | - |
| ASB10 | 0.3 | - | 0.2 | 3.9 | 2.7 | 0.8 | - |
| NRK+ | 0.9 | - | 0.1 | 1 | 2.5 | 0.3 | - |
| DSPP | 1.2 | 0.3 | 0.2 | 1.1 | 2.3 | 0.4 | - |
| MEF2A | 0.1 | - | 1.2 | 3.8 | 2.3 | 0.3 | - |
| PCDH11X | 0.8 | - | 0.9 | 2.2 | 0.3 | - | |
| CACNA1C | 1.3 | - | 0.9 | 5.1 | 2.1 | 0.3 | - |
| GRIA3 | 1.2 | 0.1 | 0.1 | 1.1 | 2.1 | 0.2 | - |
| TTN | 13.7 | - | 0.1 | 2 | 2 | - | - |
| FOXA1 | 1.3 | - | 0.8 | 4.7 | 2 | 0.4 | 84.2 |
| TBX3 | 0.9 | - | - | 1.6 | 1.9 | 0.2 | - |
| NOTCH2^ | 0.8 | - | 0.8 | 4 | 1.8 | 0.2 | - |
| ARHGAP35^ | 0.8 | - | 0.1 | 1.9 | 1.8 | 0.1 | - |
| HECTD4 | 1.2 | - | 0.1 | 1.6 | 1.5 | 0.2 | - |
| MAST1 | 1 | - | 0.2 | 3.4 | 1.4 | 0.1 | 22 |
| RUNX1^ | 1.2 | 0.1 | 0.2 | 3.5 | 1.4 | 0.1 | - |
| ADCY3+ | 0.3 | - | 0.1 | 1.9 | 1.4 | 0.1 | - |
| ROCK2 | 0.5 | - | 0.3 | 1.9 | 1.2 | 0.3 | - |
| PCBP2+ | 0.3 | - | 0.1 | 2.2 | 1.1 | 0.1 | - |
| ARID2* | 0.5 | - | 0.2 | 2.4 | 1 | 0.3 | - |
| SDK2 | 1 | - | 1.4 | 11.6 | 1 | 0.4 | - |
| OBSCN* | 1.7 | - | 1.4 | 32.9 | 1 | 0.1 | - |
| SCAF11 | 0.4 | - | 0.2 | 2.4 | 1 | 0.2 | - |
| STAT6 | 0.1 | - | 0.2 | 2.3 | 0.9 | - | - |
| GATA3* | 0.9 | 2.4 | 0.9 | 7.3 | 0.8 | 0.2 | 81.1 |
| NID1 | 1 | 0.1 | 1.6 | 33.3 | 0.8 | 0.2 | - |
| ERBB3^ | 1.3 | - | 0.1 | 2.4 | 0.8 | 0.1 | - |
| DDX11+ | 0.4 | - | 0.8 | 4.4 | 0.8 | 0.3 | - |
| FRMD4A* | 0.5 | - | 0.8 | 6.5 | 0.8 | 0.1 | - |
| PIK3CB | 0.6 | - | 0.3 | 4.8 | 0.8 | - | - |
| BIRC6 | 1.3 | - | 0.1 | 2.4 | 0.7 | 0.1 | - |
| EGFR^ | 0.6 | - | 0.8 | 4.5 | 0.7 | 0.3 | - |
| RYR2 | 3.9 | - | 3.5 | 33.1 | 0.6 | 0.3 | 5.9 |
| DNAH14 | 0.5 | 0.1 | 1.3 | 33.7 | 0.4 | 0.1 | 79.8 |
| TBL1XR1 | 0.5 | - | 0.7 | 8.2 | 0.4 | - | - |
| PIK3CA^ | 32.1 | 0.6 | 0.9 | 8 | 0.3 | - | 0.1 |
| GPRIN2 | 0.1 | 0.3 | 6.4 | 2.9 | 0.3 | - | - |
| NBPF12 | 0.3 | - | 4.5 | 45 | 0.2 | 0.1 | - |
| ASH1L | 1 | 0.1 | 1.4 | 31.2 | 0.1 | - | - |
| MLL3* | 0.8 | - | 0.8 | 4 | 1.8 | 0.2 | - |
| FLG | 4.4 | - | 2 | 30.9 | - | 0.1 | - |
Identified driver genes are categorized with Tumor suppressor (* with bold caption); Oncogene (^ with bold caption); Gatekeeper (+ with bold caption).