Table 1. Top 30 genes significantly more highly expressed in the RPE compared to the IE.
The genes that are in bold were shown to be enriched in the human RPE [26]. Asterisks mark the genes that might be present in our dataset by contamination of the mRNA on the photoreceptor-RPE interface or may be expressed to some extent in both adjacent cell layers (also see Materials and methods).
| RPE | |||
|---|---|---|---|
| GeneName | SystematicName | Adj p value | FC |
| RPE65 | NM_000329 | 6.9E-05 | 167.7 |
| PCAT4 | AK056825 | 1.2E-04 | 146.1 |
| SLCO1C1 | NM_017435 | 3.5E-05 | 138.1 |
| GNGT1 | NM_021955 | 5.9E-04 | 136.3 |
| CNGA1* | NM_000087 | 5.4E-06 | 131.2 |
| GUCA1B* | NM_002098 | 8.1E-06 | 116.1 |
| KIRREL2 | NM_199180 | 7.5E-06 | 108.3 |
| MIR124-2HG | AK124256 | 6.1E-06 | 106.3 |
| MAK | NM_005906 | 5.4E-06 | 98.5 |
| LINC00982 | AL833006 | 1.7E-05 | 96.8 |
| OPCML | NM_001012393 | 7.5E-06 | 94.8 |
| NEUROD1 | NM_002500 | 7.8E-06 | 94.4 |
| MPP4* | NM_033066 | 7.5E-06 | 93.8 |
| BEST1 | NM_004183 | 4.3E-05 | 92.9 |
| ITGB8 | NM_002214 | 4.7E-04 | 91.1 |
| DUSP6 | NM_001946 | 1.3E-04 | 89.5 |
| LRAT | NM_004744 | 4.0E-05 | 81.9 |
| NRL* | NM_006177 | 2.4E-05 | 81.5 |
| RRH | NM_006583 | 1.9E-05 | 78.3 |
| RP1* | NM_006269 | 6.1E-06 | 76.5 |
| SAG* | NM_000541 | 8.5E-05 | 75.9 |
| COL8A1 | AL359062 | 2.5E-05 | 72.9 |
| PDE6H | NM_006205 | 2.0E-05 | 72.4 |
| AIPL1* | NM_014336 | 2.0E-05 | 70.5 |
| KIAA1189 | NM_020711 | 1.7E-05 | 68.0 |
| LOC100507521 | BX101632 | 1.6E-05 | 67.6 |
| SLC26A7 | NM_052832 | 8.0E-05 | 66.2 |
| TMEM16B | NM_020373 | 7.5E-06 | 65.5 |
| GNAT2 | ENST00000351050 | 4.2E-05 | 60.8 |
| SERINC4 | ENST00000319327 | 7.5E-06 | 60.3 |