Table 3. EC50a antiparasitic activity of L. tridentata lignans 1–8 and flavonol 9.
| Compounds | E. histolytica EC50 (pEC50 ± SE) (μM) |
G. lamblia EC50 (pEC50 ± SE) (μM) |
N. fowleri EC50 (pEC50 ± SE) (μM) |
|---|---|---|---|
| 1 | 103 (4 ± 0.03) | 36 (4.4 ± 0.02) | 37 (4.4 ± 0.03) |
| 2 | 171 (3.8 ± 0.07) | 38 (4.4 ± 0.02) | 38 (4.4 ± 0.02) |
| 3 | 94 (4 ± 0.03) | 49 (4.3 ± 0.03) | 73 (4.1 ± 0.04) |
| 4 | 83 (4.1 ± 0.04) | 74 (4.1 ± 0.02) | 75 (4.1 ± 0.02) |
| 5 | 236 (3.6 ± 0.03) | 188 (3.7 ± 0.02) | 155 (3.8 ± 0.01) |
| 6 | 146 (3.8 ± 0.02) | 96 (4 ± 0.07) | 150 (3.8 ± 0.02) |
| 7 | — | — | — |
| 8 | — | — | — |
| 9 | — | 153 (3.8 ± 0.02) | 235 (3.6 ± 0.02) |
| Metronidazole | 5 (5.3 ± 0.03) | 6.4 (5.2 ± 0.02) | — |
| Miltefosine | — | — | 54.5 (4.3 ± 0.01) |
aEC50 minimum n = 3
(—) represents inactivity