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. Author manuscript; available in PMC: 2017 Aug 21.
Published in final edited form as: J Med Chem. 2015 Apr 17;58(9):3794–3805. doi: 10.1021/jm501984f

Figure 2.

Figure 2

X-ray structures of tricyclic indole acids bound to Mcl-1. (A) Compounds 17 and 24 interact with Mcl-1 in the BH3-peptide binding cleft between helices 3, 4, and 5. The indole cores and naphthyl groups adopt almost the same binding poses while C-ring units adopt different binding conformations (inset). Shown is the surface depiction of Mcl-1 when complexed to (B) Compound 17 and (C) Compound 24 that illustrates how these ligands occupy the P2 pocket. Arrows indicate potential positions for substitutions to fill unoccupied sub-sites.