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Compound 34 inhibits binding of biotin-MS-1 to Mcl-1 in cell lysates. K562 cell lysates were incubated with compound or a Bim-BH3 peptide positive control at indicated concentrations. Streptavidin-conjugated beads bound with biotin-MS-1 were incubated with the lysates to pulldown cellular Mcl-1, which was visualized by Western blot.
