Figure 2. SLAM receptors are required for phagocytosis of haematopoietic cells.

a, Same as Fig. 1d, using macrophages from WT or SFR KO mice. b, Same as a, using human targets. c, Same as Fig. 1e, using SFR KO macrophages. d, Phagocytosis of parental or CD47 KO L1210. e, Intraperitoneal tumour clearance assay using L1210 cells. f, Same as e, except WT mice were injected with liposomes containing clodronate or phosphate-buffered saline (PBS). g, Growth of L1210 injected subcutaneously in RAG-1 KO or RAG-1 SFR dKO mice. D, day. *P <0.05; **P <0.01; ***P <0.001; ****P <0.0001 (two-tailed Student’s t-tests). Results pooled from a total of eight (L1210), six (P815), seven (WEHI-3) or five (CB17–3A8, SP2/0) (a), five (b, d), three (c), and two (f) mice studied in independent experiments; six mice from five independent experiments (e); and 11 mice from two of four independent experiments (g). Each symbol represents one mouse. For g, bar graphs represent mean volumes. All data are means ± s.e.m. See also Extended Data Figs 3 and 4 and Source Data for this figure are available in the online version of the paper.