Fig. S6.

MeCP2 regulation of long genes in sensory neurons. (A) IPA of up-regulated genes with >100-kb length was conducted to examine affected biological pathways in sequencing data from KO rats. Negative logarithm to the base 10 of P values of significantly associated categories in functions. Long genes up-regulated in the category of “Cellular assembly and organization.” (B) Canonical pathways implicated in MeCP2 functions identified by up-regulation of long genes alone in KO rats. (C) qPCR of selected long genes in WT rats shows gene function was affected only at high concentrations of topotecan.