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CRY-deficient mice exhibit reduced anesthesia sleep time. (A) Cyp2b10, Cyp3a11, and Cyp3a13 gene expression in livers from female dKO mice and WT littermates. n = 4–5 female animals per group. *P < 0.05, **P < 0.01, ***P < 0.005 by t test. (B) Duration of ketamine induced sleep in dKO mice and WT littermates. n (female) = 6–15 per genotype, n (male) = 10–22 per genotype. n.s., not significant; *P < 0.05, **P < 0.01 by two-way ANOVA.
