Fig. 6.

Model for CED-11 function in apoptosis. CED-11 acts downstream of CED-3 to promote cell-autonomous death and degradation in parallel with engulfment and phagosome-mediated degradation. CED-11 is directly or indirectly activated by the CED-3 caspase. CED-11 activation results in a decrease in cell volume, driving an increase in macromolecule density and leading to the observed increases in cellular refractility and electron density. CED-11–mediated changes in the apoptotic cell promote its death and degradation. (A) Pathway. (B) Schematic.