Table I.

Overview of the Patient Characteristics of the Model Developed for Amikacin Applied in the Models Using the Amikacin Covariate Model and of the Different Datasets Used in the Current Analysis as Basis for the Models Using the Amikacin Covariate Model and the Independent Reference Models

Dataset	Amikacin dataset (16)	Datasets used in this analysis
	Amikacin (16)	Netilmicin (17)	Tobramycin (18)	Vancomycin (19)	Gentamicin A (20)	Gentamicin B (21)
Number of patients	874	88	470	273	673	59
Gestational age (weeks)	32 (24–43)	28 (23–41)	32 (24–43)	29 (23–34)	34 (23–43)	29 (23–42)
Postmenstrual age (weeks)	33 (24–43)	30 (23–44)	32 (24–43)	30 (24–38)	36 (23–44)	30 (23–42)
Postnatal age (days)	2 (1–30)	15 (3–30)	2 (1–4)	14 (1–28)	3 (1–30)	6 (1–30)
Birth bodyweight (g)	1,750 (385–4,650)	1,000 (470–3,000)	1,530 (485–5,245)	1,140 (385–2,550)	2,350 (440–5,240)	1,279 (520–4,950)
Current bodyweight (g)	1,760 (385–4,760)	1,115 (470–3,592)	–	1,170 (415–2,630)	2,550 (440–5,420)	1,009 (480–5,315)
Co-administration of ibuprofen or indomethacin (n(%))	118 (13.5)	–	45 (9.6)	23 (8.4)	70 (10.4)	6 (10.2)

Values are expressed as median (range)