Table 3.

Hub genes in six obesity-related disease/system networks

Network name	Seed node average degree	Hub gene
Coronary artery disease (CAD)	11.03	ESR1, F2, NFKB1, SRC, PTGS2, IL6, PPARA, TP53
Diabetes	13.17	TP53, JUN, AKT1, INS
Hypertension	17.71	SRC, JUN, AKT1
Breast cancer	4.28	RUNX1, PIK3CA, EP300, BRCA1, SMARCD1, SMAD4, AKT1, TP53
Polycystic ovary syndrome (PCOS)	8.65	CYP17A1, AR, BMP2, VEGFA, IGF1, IL6, TGFB1, ESR1, AKT1, POMC, JUN, INS
Kidney cancer	1.01	TSC2, MTOR, PTEN, TP53, SMARCB1, ERCC2, KDM6A