Figure 6.
Embryonic Septal NKX2-1 Is Essential for Learning and Memory
(A) NOR task with 10 min and 24 hr inter-trial intervals (n = 9). FAM, familiarization session, TEST, test session. Mutant mice show a lower discrimination index at both intervals. Mean discrimination index ± SEM. Two-way RM ANOVA. Post hoc uncorrected Fisher’s LSD, ∗p < 0.05, ∗∗p < 0.001, and ∗∗∗p < 0.0001.
(B) Crawley’s social memory test (n = 8). The mutant mice display normal social memory. Mean discrimination index ± SEM, unpaired two-tailed t test.
(C) Object location task with 10 min and 24 hr ITIs (n = 9). The mutant mice display lower discrimination index. Mean discrimination index ± SEM. Two-way RM ANOVA. Post hoc uncorrected Fisher’s LSD, ∗p < 0.05, ∗∗p < 0.001, and ∗∗∗p < 0.0001.
(D) T-maze task over 8 consecutive days (n = 8). The mutant mice never perform above chance level (dashed line). The data show mean percentages of correct choices over each day ±SEM (ten trials per day). Two-way RM ANOVA. Post hoc uncorrected Fisher’s LSD, ∗p < 0.05, ∗∗p < 0.001, and ∗∗∗p < 0.0001.