Table 3.

Body weight decrease in ExeOW randomized clinical trials of at least 26 weeks

ExeOW Study	LS mean body weight decrease (kg)
	ExeOW	ExeBID	SITA	PIO	GLAR	MET	PIO	SITA	LIRA	DET
DURATION-1 [8]	−3.7	−3.6
DURATION-2 [12]	−2.3		−0.3 §	2.8 ¶
DURATION-3 [13]	−2.6				1.4*
DURATION-4 [11]	−2					−2	1.5*	0.3*
DURATION-5 [14]	−2.3	−1.4
DURATION-6 [15]	−2.7								−3.6

EXEOW exenatide once weekly, EXEBID exenatide twice a day, SITA sitagliptin, PIO pioglitazone, GLAR insulin glargine, MET metformin, LIRA liraglutide, DET insulin detemir

* p < 0.001, § p = 0.0002, ¶ p < 0.0001