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. Author manuscript; available in PMC: 2018 Sep 17.
Published in final edited form as: Neuroscience. 2017 Jul 4;359:1–7. doi: 10.1016/j.neuroscience.2017.06.057

Figure 4. The inhibitory postsynaptic currents (IPSCs) and GABAergic neurotransmission to the XII MNs are reduced in LgDel P7-P17 pups.

Figure 4

Typical examples are displayed the decrease in IPSCs frequency (top two traces, WT:left trace, LgDel: right trace), spontaneous GABAergic IPSCs frequency (middle traces), as well as miniature GABAergic IPSCs (bottom traces) of XII MNs in the LgDel mice. The IPSCs frequency is significantly (p=0.0049) lower in LgDel compared to WT mice. GABAergic IPSC frequency (middle traces), as well as GABA mIPSC frequency (lower traces) is also significantly diminished in 22q11DS mice compared to wild type siblings (p=0.01 and p=0.04, respectively). Bottom scatter plots showing statistical comparisons between WT and LgDel animals for the frequency of spontaneous IPSCs, GABAergic IPSCs as well as GABAergic miniature IPSCs.