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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Pharmacol Ther. 2017 Mar 6;177:96–107. doi: 10.1016/j.pharmthera.2017.03.001

Fig. 1.

Fig. 1

DUBs contribute to key events of metastatic cascade. DUBs play important role in various events during the metastatic progression, such as EMT, ECM degradation, cell fate regulation, as well as resistance of anoikis in the circulation. The critical role of DUBs in regulating EMT is summarized, including USP4, UCHL1, UCHL3, USP22 and USP47. The importance of DUBs participated in MMPs regulation is summarized, including USP6, USP22, USP2 and USP42. The involvement of DUBs in cell fates determinants is summarized, including USP21, USP13, USP1, PSMD14, USP7, USP15 and USP21. The important DUBs that have been reported in regulating anoikis regulation include USP9X and ATAXIN-3. DUBs with known targeting proteins or without clear substrates are all listed in the order of the events in which they are evolved.