Table 2.

Predicted relapse rates during treatment period, by treatment group and selected potential moderators

		XR-NTX	TAU	Main effect	Interaction*
Attribute (Potential moderator)		Proportion Relapsed (95% CI)		P value
Alcohol intoxication: 30 days†	Yes	0.56 (0.33, 0.79)	0.58 (0.36, 0.73)	0.41	0.04
	No	0.41 (0.32, 0.49)	0.65 (0.57, 0.73)
Non-heroin opioid use: 30 days†	Yes	0.45 (0.28, 0.63)	0.77 (0.61, 0.93)	0.03	0.14
	No	0.41 (0.32, 0.50)	0.61 (0.53, 0.70)
Risk Assessment Battery – drug risk score‡
	5	0.40 (0.27, 0.53)	0.74 (0.61, 0.87)	0.08	0.12
	0	0.44 (0.36, 0.53)	0.61 (0.52, 0.69)
Addiction Severity Index – family/social score†
	0.2	0.36 (0.26, 0.46)	0.67 (0.57, 0.77)	0.07	0.07
	0	0.46 (0.36, 0.56)	0.63 (0.53, 0.73)
Suicidal thoughts§	Yes	0.36 (0.08, 0.65)	0.83 (0.54, 1.00)	0.09	0.08
	No	0.43 (0.35, 0.51)	0.62 (0.55, 0.70)
Mobility limitationsǁ	Yes	0.47 (0.31, 0.64)	0.53 (0.36, 0.70)	0.20	0.09
	No	0.42 (0.33, 0.51)	0.67 (0.59, 0.75)

^*Potential modifier*treatment group interaction, selected for those at P<0.15

^†From the Addiction Severity Index-Lite (McLellan et al., 1992).

^‡From the Risk Assessment Battery (Watkins et al., 1992)

^§From the Mini-International Neuropsychiatric Interview (Sheehan et al., 1998).

^ǁFrom the Euroquol EQ-5D Quality of Life scale (EuroQol, 1990)