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. 2017 Aug 16;7:33–40. doi: 10.1016/j.bonr.2017.08.001

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1. — Nucleosome and chromatin modification via histone acetylation. A) A nucleosome includes DNA wrapping around a histone octamer, containing two molecules of each histone H2A, H2B, H3, H4; acetyl group such as Lysin 9 (K9) on histone tail. B) Transcriptional inactivation and activation via the acetylation of histones which controls by HAT (activation) and HDAC (inactivation). HATs transfer the acetyl moiety to histone tail and HDACs remove this group from the histones comprising the nucleosome.